Liposome formulations of o-carborane for the boron neutron capture therapy of cancer
Research output: Contribution to journal › Article › peer-review
Based on the promise of liposomes as convenient vehicles for the transport of boronated agents for the boron neutron capture therapy (BCNT) of cancer, this paper reports a method for the formulation and characterisation of stable o-carborane-loaded liposomes (ca. 80 – 100 nm) of dipalmitoyl-phosphatidylcholine (DPPC) or 1,2-distearol-sn-glycerol-3-phosphocholine (DSPC). Preliminary pharmaceutical characterisation experiments have demonstrated the integrity of both DPPC and DSPC liposomal membranes in serum and in PBS and also indicate that these o-carborane-loaded liposomes are candidate carrier vehicles for further evaluation with a view to exploitation in BNCT.
| Original language | English |
|---|---|
| Pages (from-to) | 25-33 |
| Journal | Biophysical Chemistry |
| Volume | 247 |
| Early online date | 15 Feb 2019 |
| DOIs | |
| Publication status | Published - Apr 2019 |
Documents
- 2019_BiophysChem_postprint
Accepted author manuscript (Post-print), 1.04 MB, PDF document
Licence: CC BY-NC-ND
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Projects
Student Theses
Formulation and preliminary evaluation of delivery vehicles for the boron neutron capture therapy of cancer
Student thesis: Doctoral Thesis
ID: 12869181
