Liposome formulations of o-carborane for the boron neutron capture therapy of cancer

Temidayo Olusanya; Gianpiero Calabrese; Dimitrios G. Fatouros; John Tsibouklis; James Smith

doi:10.1016/j.bpc.2019.01.003

Liposome formulations of o-carborane for the boron neutron capture therapy of cancer

Research output: Contribution to journal › Article › peer-review

Temidayo Olusanya
Gianpiero Calabrese
Dimitrios G. Fatouros
Dr John Tsibouklis
Dr James Smith

Based on the promise of liposomes as convenient vehicles for the transport of boronated agents for the boron neutron capture therapy (BCNT) of cancer, this paper reports a method for the formulation and characterisation of stable o-carborane-loaded liposomes (ca. 80 – 100 nm) of dipalmitoyl-phosphatidylcholine (DPPC) or 1,2-distearol-sn-glycerol-3-phosphocholine (DSPC). Preliminary pharmaceutical characterisation experiments have demonstrated the integrity of both DPPC and DSPC liposomal membranes in serum and in PBS and also indicate that these o-carborane-loaded liposomes are candidate carrier vehicles for further evaluation with a view to exploitation in BNCT.

Original language	English
Pages (from-to)	25-33
Journal	Biophysical Chemistry
Volume	247
Early online date	15 Feb 2019
DOIs	https://doi.org/10.1016/j.bpc.2019.01.003
Publication status	Published - Apr 2019

Documents

2019_BiophysChem_postprint
Accepted author manuscript (Post-print), 1.04 MB, PDF document
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