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Liposome formulations of o-carborane for the boron neutron capture therapy of cancer

Research output: Contribution to journalArticle

Based on the promise of liposomes as convenient vehicles for the transport of boronated agents for the boron neutron capture therapy (BCNT) of cancer, this paper reports a method for the formulation and characterisation of stable o-carborane-loaded liposomes (ca. 80 – 100 nm) of dipalmitoyl-phosphatidylcholine (DPPC) or 1,2-distearol-sn-glycerol-3-phosphocholine (DSPC). Preliminary pharmaceutical characterisation experiments have demonstrated the integrity of both DPPC and DSPC liposomal membranes in serum and in PBS and also indicate that these o-carborane-loaded liposomes are candidate carrier vehicles for further evaluation with a view to exploitation in BNCT.
Original languageEnglish
Pages (from-to)25-33
JournalBiophysical Chemistry
Volume247
Early online date15 Feb 2019
DOIs
Publication statusPublished - Apr 2019

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  • 2019_BiophysChem_postprint

    Accepted author manuscript (Post-print), 1 MB, PDF document

    Due to publisher’s copyright restrictions, this document is not freely available to download from this website until: 15/02/21

    Licence: CC BY-NC-ND

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