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Liposome formulations of o-carborane for the boron neutron capture therapy of cancer

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Liposome formulations of o-carborane for the boron neutron capture therapy of cancer. / Olusanya, Temidayo; Calabrese, Gianpiero; Fatouros, Dimitrios G.; Tsibouklis, John; Smith, James.

In: Biophysical Chemistry, Vol. 247, 04.2019, p. 25-33.

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Olusanya, Temidayo ; Calabrese, Gianpiero ; Fatouros, Dimitrios G. ; Tsibouklis, John ; Smith, James. / Liposome formulations of o-carborane for the boron neutron capture therapy of cancer. In: Biophysical Chemistry. 2019 ; Vol. 247. pp. 25-33.

Bibtex

@article{6551cf7bc4f640e6821550d137c55844,
title = "Liposome formulations of o-carborane for the boron neutron capture therapy of cancer",
abstract = "Based on the promise of liposomes as convenient vehicles for the transport of boronated agents for the boron neutron capture therapy (BCNT) of cancer, this paper reports a method for the formulation and characterisation of stable o-carborane-loaded liposomes (ca. 80 – 100 nm) of dipalmitoyl-phosphatidylcholine (DPPC) or 1,2-distearol-sn-glycerol-3-phosphocholine (DSPC). Preliminary pharmaceutical characterisation experiments have demonstrated the integrity of both DPPC and DSPC liposomal membranes in serum and in PBS and also indicate that these o-carborane-loaded liposomes are candidate carrier vehicles for further evaluation with a view to exploitation in BNCT.",
keywords = "liposomes, Cancer, BNCT, Nanoparticles, embargoover12",
author = "Temidayo Olusanya and Gianpiero Calabrese and Fatouros, {Dimitrios G.} and John Tsibouklis and James Smith",
note = "24 month embargo",
year = "2019",
month = "4",
doi = "10.1016/j.bpc.2019.01.003",
language = "English",
volume = "247",
pages = "25--33",
journal = "Biophysical Chemistry",
issn = "0301-4622",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Liposome formulations of o-carborane for the boron neutron capture therapy of cancer

AU - Olusanya, Temidayo

AU - Calabrese, Gianpiero

AU - Fatouros, Dimitrios G.

AU - Tsibouklis, John

AU - Smith, James

N1 - 24 month embargo

PY - 2019/4

Y1 - 2019/4

N2 - Based on the promise of liposomes as convenient vehicles for the transport of boronated agents for the boron neutron capture therapy (BCNT) of cancer, this paper reports a method for the formulation and characterisation of stable o-carborane-loaded liposomes (ca. 80 – 100 nm) of dipalmitoyl-phosphatidylcholine (DPPC) or 1,2-distearol-sn-glycerol-3-phosphocholine (DSPC). Preliminary pharmaceutical characterisation experiments have demonstrated the integrity of both DPPC and DSPC liposomal membranes in serum and in PBS and also indicate that these o-carborane-loaded liposomes are candidate carrier vehicles for further evaluation with a view to exploitation in BNCT.

AB - Based on the promise of liposomes as convenient vehicles for the transport of boronated agents for the boron neutron capture therapy (BCNT) of cancer, this paper reports a method for the formulation and characterisation of stable o-carborane-loaded liposomes (ca. 80 – 100 nm) of dipalmitoyl-phosphatidylcholine (DPPC) or 1,2-distearol-sn-glycerol-3-phosphocholine (DSPC). Preliminary pharmaceutical characterisation experiments have demonstrated the integrity of both DPPC and DSPC liposomal membranes in serum and in PBS and also indicate that these o-carborane-loaded liposomes are candidate carrier vehicles for further evaluation with a view to exploitation in BNCT.

KW - liposomes

KW - Cancer

KW - BNCT

KW - Nanoparticles

KW - embargoover12

U2 - 10.1016/j.bpc.2019.01.003

DO - 10.1016/j.bpc.2019.01.003

M3 - Article

VL - 247

SP - 25

EP - 33

JO - Biophysical Chemistry

JF - Biophysical Chemistry

SN - 0301-4622

ER -

ID: 12869181