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Minor neurological signs and behavioural function at age 2 years in neonatal hypoxic ischaemic encephalopathy (HIE)

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Minor neurological signs and behavioural function at age 2 years in neonatal hypoxic ischaemic encephalopathy (HIE). / Edmonds, Caroline J.; Helps, Suzannah K.; Hart, Denise; Zatorska, Anna; Gupta, Neelam; Cianfaglione, Rina; Vollmer, Brigitte.

In: European Journal of Paediatric Neurology, 11.04.2020.

Research output: Contribution to journalArticlepeer-review

Harvard

Edmonds, CJ, Helps, SK, Hart, D, Zatorska, A, Gupta, N, Cianfaglione, R & Vollmer, B 2020, 'Minor neurological signs and behavioural function at age 2 years in neonatal hypoxic ischaemic encephalopathy (HIE)', European Journal of Paediatric Neurology. https://doi.org/10.1016/j.ejpn.2020.04.003

APA

Edmonds, C. J., Helps, S. K., Hart, D., Zatorska, A., Gupta, N., Cianfaglione, R., & Vollmer, B. (2020). Minor neurological signs and behavioural function at age 2 years in neonatal hypoxic ischaemic encephalopathy (HIE). European Journal of Paediatric Neurology. https://doi.org/10.1016/j.ejpn.2020.04.003

Vancouver

Edmonds CJ, Helps SK, Hart D, Zatorska A, Gupta N, Cianfaglione R et al. Minor neurological signs and behavioural function at age 2 years in neonatal hypoxic ischaemic encephalopathy (HIE). European Journal of Paediatric Neurology. 2020 Apr 11. https://doi.org/10.1016/j.ejpn.2020.04.003

Author

Edmonds, Caroline J. ; Helps, Suzannah K. ; Hart, Denise ; Zatorska, Anna ; Gupta, Neelam ; Cianfaglione, Rina ; Vollmer, Brigitte. / Minor neurological signs and behavioural function at age 2 years in neonatal hypoxic ischaemic encephalopathy (HIE). In: European Journal of Paediatric Neurology. 2020.

Bibtex

@article{9a6372a613eb4b32a0980591b0b93f10,
title = "Minor neurological signs and behavioural function at age 2 years in neonatal hypoxic ischaemic encephalopathy (HIE)",
abstract = "Background: Neurodevelopmental follow-up in Neonatal Hypoxic Ischaemic Encephalopathy (HIE) typically focusses on major neuromotor (cerebral palsy, CP) and severe cognitive impairment. Outcomes in those without major neuromotor impairment are less well explored.Objectives: To examine behavioural, cognitive and neurological outcomes after neonatal HIE, in a clinical cohort of children without CP, at age 2 years.Methods: Clinical routine outcome data from children admitted to a tertiary centre with neonatal HIE for hypothermia treatment between 05/08/09–30/05/2016. Children were assessed for neuromotor status – particularly minor neurological signs (MNS), with Bayley Scales of Infant and Toddler Development III (Bayley III) or Ages and Stages Questionnaire-3 (ASQ), Child Behavior Checklist 1.5–5 (CBCL), Quantitative Checklist for Autism in Toddlers (Q-CHAT).Results: Of 107 children, 75.5% had normal neurology, 12.1% CP, 12.1% MNS. Children with CP were excluded from analyses. For those without CP, Bayley-III scores were in the average range for the majority; mild cognitive delay observed in 5%, 4.2% language, 1.3% motor development; severe delay in 1.3% for cognitive, 4.2% for language. More than in the normative population scored in clinical ranges for CBCL externalising, sleep, and other problems. No significant difference was seen for Q-CHAT. Children with MNS were significantly more likely to have impaired Bayley-III scores, parent-reported internalising, sleep, and other problems.Conclusions: In this clinical cohort, the majority of children had favourable outcome at 2 years. However, children with MNS were at risk for cognitive and behavioural difficulties and will benefit from enhanced clinical follow-up and support.",
author = "Edmonds, {Caroline J.} and Helps, {Suzannah K.} and Denise Hart and Anna Zatorska and Neelam Gupta and Rina Cianfaglione and Brigitte Vollmer",
year = "2020",
month = apr,
day = "11",
doi = "10.1016/j.ejpn.2020.04.003",
language = "English",
journal = "European Journal of Paediatric Neurology",
issn = "1090-3798",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Minor neurological signs and behavioural function at age 2 years in neonatal hypoxic ischaemic encephalopathy (HIE)

AU - Edmonds, Caroline J.

AU - Helps, Suzannah K.

AU - Hart, Denise

AU - Zatorska, Anna

AU - Gupta, Neelam

AU - Cianfaglione, Rina

AU - Vollmer, Brigitte

PY - 2020/4/11

Y1 - 2020/4/11

N2 - Background: Neurodevelopmental follow-up in Neonatal Hypoxic Ischaemic Encephalopathy (HIE) typically focusses on major neuromotor (cerebral palsy, CP) and severe cognitive impairment. Outcomes in those without major neuromotor impairment are less well explored.Objectives: To examine behavioural, cognitive and neurological outcomes after neonatal HIE, in a clinical cohort of children without CP, at age 2 years.Methods: Clinical routine outcome data from children admitted to a tertiary centre with neonatal HIE for hypothermia treatment between 05/08/09–30/05/2016. Children were assessed for neuromotor status – particularly minor neurological signs (MNS), with Bayley Scales of Infant and Toddler Development III (Bayley III) or Ages and Stages Questionnaire-3 (ASQ), Child Behavior Checklist 1.5–5 (CBCL), Quantitative Checklist for Autism in Toddlers (Q-CHAT).Results: Of 107 children, 75.5% had normal neurology, 12.1% CP, 12.1% MNS. Children with CP were excluded from analyses. For those without CP, Bayley-III scores were in the average range for the majority; mild cognitive delay observed in 5%, 4.2% language, 1.3% motor development; severe delay in 1.3% for cognitive, 4.2% for language. More than in the normative population scored in clinical ranges for CBCL externalising, sleep, and other problems. No significant difference was seen for Q-CHAT. Children with MNS were significantly more likely to have impaired Bayley-III scores, parent-reported internalising, sleep, and other problems.Conclusions: In this clinical cohort, the majority of children had favourable outcome at 2 years. However, children with MNS were at risk for cognitive and behavioural difficulties and will benefit from enhanced clinical follow-up and support.

AB - Background: Neurodevelopmental follow-up in Neonatal Hypoxic Ischaemic Encephalopathy (HIE) typically focusses on major neuromotor (cerebral palsy, CP) and severe cognitive impairment. Outcomes in those without major neuromotor impairment are less well explored.Objectives: To examine behavioural, cognitive and neurological outcomes after neonatal HIE, in a clinical cohort of children without CP, at age 2 years.Methods: Clinical routine outcome data from children admitted to a tertiary centre with neonatal HIE for hypothermia treatment between 05/08/09–30/05/2016. Children were assessed for neuromotor status – particularly minor neurological signs (MNS), with Bayley Scales of Infant and Toddler Development III (Bayley III) or Ages and Stages Questionnaire-3 (ASQ), Child Behavior Checklist 1.5–5 (CBCL), Quantitative Checklist for Autism in Toddlers (Q-CHAT).Results: Of 107 children, 75.5% had normal neurology, 12.1% CP, 12.1% MNS. Children with CP were excluded from analyses. For those without CP, Bayley-III scores were in the average range for the majority; mild cognitive delay observed in 5%, 4.2% language, 1.3% motor development; severe delay in 1.3% for cognitive, 4.2% for language. More than in the normative population scored in clinical ranges for CBCL externalising, sleep, and other problems. No significant difference was seen for Q-CHAT. Children with MNS were significantly more likely to have impaired Bayley-III scores, parent-reported internalising, sleep, and other problems.Conclusions: In this clinical cohort, the majority of children had favourable outcome at 2 years. However, children with MNS were at risk for cognitive and behavioural difficulties and will benefit from enhanced clinical follow-up and support.

UR - https://linkinghub.elsevier.com/retrieve/pii/S109037982030074X

U2 - 10.1016/j.ejpn.2020.04.003

DO - 10.1016/j.ejpn.2020.04.003

M3 - Article

JO - European Journal of Paediatric Neurology

JF - European Journal of Paediatric Neurology

SN - 1090-3798

ER -

ID: 20696771