Skip to content

Modulating autophagy as a therapeutic strategy for the treatment of paediatric high grade glioma

Research output: Contribution to journalReview articlepeer-review

  • Alison Howarth
  • Patricia A. Madureira
  • George Lockwood
  • Lisa C. D. Storer
  • Richard Grundy
  • Ruman Rahman
  • Geoffrey J. Pilkington
  • Richard Hill

Paediatric high grade glioma (pHGG) represent a therapeutically challenging group of tumours. Despite decades of research there has been a minimal improvement in treatment and the clinical prognosis remains poor. Autophagy, a highly conserved process for recycling metabolic substrates is upregulated in pHGG, promoting tumour progression and evading cell death. There is significant cross talk between autophagy and a plethora of critical cellular pathways, many of which are dysregulated in pHGG. The following article will discuss our current understanding of autophagy signalling in pHGG and the potential modulation of this network as a therapeutic target.

Original languageEnglish
Number of pages19
JournalBrain Pathology
Early online date13 May 2019
Publication statusEarly online - 13 May 2019


  • Howarth_et_al-2019-Brain_Pathology

    Rights statement: This is the peer reviewed version of the following article: Howarth, A. , Madureira, P. A., Lockwood, G. , Storer, L. C., Grundy, R. , Rahman, R. , Pilkington, G. J. and Hill, R. (2019), Modulating Autophagy as a Therapeutic Strategy for the Treatment of Paediatric High Grade Glioma. Brain Pathol., which has been published in final form at doi:10.1111/bpa.12729. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.

    Accepted author manuscript (Post-print), 1.67 MB, PDF document

Related information

Relations Get citation (various referencing formats)

ID: 13818290