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Nano carriers for drug transport across the blood brain barrier

Research output: Contribution to journalArticle

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Nano carriers for drug transport across the blood brain barrier. / Li, Xinming; Tsibouklis, John; Weng, Tingting; Zhang, Buning; Yin, Guoqiang; Feng, Guangzhu; Cui, Yingde; Savina, Irina N; Mikhalovska, Lyuba I; Sandeman, Susan R; Howel, Carol A; Mikhalovsky, Sergey V.

In: Journal of Drug Targeting, Vol. 25, No. 1, 01.2017, p. 17-28.

Research output: Contribution to journalArticle

Harvard

Li, X, Tsibouklis, J, Weng, T, Zhang, B, Yin, G, Feng, G, Cui, Y, Savina, IN, Mikhalovska, LI, Sandeman, SR, Howel, CA & Mikhalovsky, SV 2017, 'Nano carriers for drug transport across the blood brain barrier', Journal of Drug Targeting, vol. 25, no. 1, pp. 17-28. https://doi.org/10.1080/1061186X.2016.1184272

APA

Li, X., Tsibouklis, J., Weng, T., Zhang, B., Yin, G., Feng, G., ... Mikhalovsky, S. V. (2017). Nano carriers for drug transport across the blood brain barrier. Journal of Drug Targeting, 25(1), 17-28. https://doi.org/10.1080/1061186X.2016.1184272

Vancouver

Li X, Tsibouklis J, Weng T, Zhang B, Yin G, Feng G et al. Nano carriers for drug transport across the blood brain barrier. Journal of Drug Targeting. 2017 Jan;25(1):17-28. https://doi.org/10.1080/1061186X.2016.1184272

Author

Li, Xinming ; Tsibouklis, John ; Weng, Tingting ; Zhang, Buning ; Yin, Guoqiang ; Feng, Guangzhu ; Cui, Yingde ; Savina, Irina N ; Mikhalovska, Lyuba I ; Sandeman, Susan R ; Howel, Carol A ; Mikhalovsky, Sergey V. / Nano carriers for drug transport across the blood brain barrier. In: Journal of Drug Targeting. 2017 ; Vol. 25, No. 1. pp. 17-28.

Bibtex

@article{52dca9de99ac4586b0c2fffa18625546,
title = "Nano carriers for drug transport across the blood brain barrier",
abstract = "Effective therapy lies in achieving a therapeutic amount of drug to the proper site in the body and then maintaining the desired drug concentration for a sufficient time interval to be clinically effective for treatment. The blood brain barrier (BBB) hinders most drugs from entering the central nervous system (CNS) from the blood stream, leading to the difficulty of delivering drugsto the brain via the circulatory system for the treatment, diagnosis and prevention of brain diseases. Several brain drug delivery approaches have been developed such as intracerebral and intracerebroventricular administration, intranasal delivery, and blood-to-brain delivery as a result of transient BBB disruption induced by biological, chemical or physical stimuli such as zonula occludens toxin, mannitol, magnetic heating and ultrasound, but these approaches showed disadvantages of being dangerous, high cost as well as unsuitability for most brain diseases and drugs. The strategy of vector-mediated blood-to-brain delivery which involves improving BBB permeability of the drug-carrier conjugate can minimize such side effects; being submicrometre objects that behave as a whole unit in terms of their transport and properties, nanomaterials are promising carrier vehicles for direct drug transport across the intact BBB as a result of their potential to enter the brain capillary endothelial cells by means of normal endocytosis and transcytosis due to their small size, as well as their possibility of being functionalized with multiple copies of the drug molecule of interest. This review provids a concise discussion of nano carriers for drug transport across the intact BBB, various forms of nanomaterials including inorganic/solid lipid/polymeric nanoparticles, nanoemulsions, quantum dots, nanogels, liposomes, micelles, dendrimers, polymersomes and exosomes are critically evaluated, their mechanisms for drug transport across the BBB are reviewed, and the future directions of this area are fully discussed.",
author = "Xinming Li and John Tsibouklis and Tingting Weng and Buning Zhang and Guoqiang Yin and Guangzhu Feng and Yingde Cui and Savina, {Irina N} and Mikhalovska, {Lyuba I} and Sandeman, {Susan R} and Howel, {Carol A} and Mikhalovsky, {Sergey V}",
year = "2017",
month = "1",
doi = "10.1080/1061186X.2016.1184272",
language = "English",
volume = "25",
pages = "17--28",
journal = "Journal of Drug Targeting",
issn = "1061-186X",
publisher = "Informa Healthcare",
number = "1",

}

RIS

TY - JOUR

T1 - Nano carriers for drug transport across the blood brain barrier

AU - Li, Xinming

AU - Tsibouklis, John

AU - Weng, Tingting

AU - Zhang, Buning

AU - Yin, Guoqiang

AU - Feng, Guangzhu

AU - Cui, Yingde

AU - Savina, Irina N

AU - Mikhalovska, Lyuba I

AU - Sandeman, Susan R

AU - Howel, Carol A

AU - Mikhalovsky, Sergey V

PY - 2017/1

Y1 - 2017/1

N2 - Effective therapy lies in achieving a therapeutic amount of drug to the proper site in the body and then maintaining the desired drug concentration for a sufficient time interval to be clinically effective for treatment. The blood brain barrier (BBB) hinders most drugs from entering the central nervous system (CNS) from the blood stream, leading to the difficulty of delivering drugsto the brain via the circulatory system for the treatment, diagnosis and prevention of brain diseases. Several brain drug delivery approaches have been developed such as intracerebral and intracerebroventricular administration, intranasal delivery, and blood-to-brain delivery as a result of transient BBB disruption induced by biological, chemical or physical stimuli such as zonula occludens toxin, mannitol, magnetic heating and ultrasound, but these approaches showed disadvantages of being dangerous, high cost as well as unsuitability for most brain diseases and drugs. The strategy of vector-mediated blood-to-brain delivery which involves improving BBB permeability of the drug-carrier conjugate can minimize such side effects; being submicrometre objects that behave as a whole unit in terms of their transport and properties, nanomaterials are promising carrier vehicles for direct drug transport across the intact BBB as a result of their potential to enter the brain capillary endothelial cells by means of normal endocytosis and transcytosis due to their small size, as well as their possibility of being functionalized with multiple copies of the drug molecule of interest. This review provids a concise discussion of nano carriers for drug transport across the intact BBB, various forms of nanomaterials including inorganic/solid lipid/polymeric nanoparticles, nanoemulsions, quantum dots, nanogels, liposomes, micelles, dendrimers, polymersomes and exosomes are critically evaluated, their mechanisms for drug transport across the BBB are reviewed, and the future directions of this area are fully discussed.

AB - Effective therapy lies in achieving a therapeutic amount of drug to the proper site in the body and then maintaining the desired drug concentration for a sufficient time interval to be clinically effective for treatment. The blood brain barrier (BBB) hinders most drugs from entering the central nervous system (CNS) from the blood stream, leading to the difficulty of delivering drugsto the brain via the circulatory system for the treatment, diagnosis and prevention of brain diseases. Several brain drug delivery approaches have been developed such as intracerebral and intracerebroventricular administration, intranasal delivery, and blood-to-brain delivery as a result of transient BBB disruption induced by biological, chemical or physical stimuli such as zonula occludens toxin, mannitol, magnetic heating and ultrasound, but these approaches showed disadvantages of being dangerous, high cost as well as unsuitability for most brain diseases and drugs. The strategy of vector-mediated blood-to-brain delivery which involves improving BBB permeability of the drug-carrier conjugate can minimize such side effects; being submicrometre objects that behave as a whole unit in terms of their transport and properties, nanomaterials are promising carrier vehicles for direct drug transport across the intact BBB as a result of their potential to enter the brain capillary endothelial cells by means of normal endocytosis and transcytosis due to their small size, as well as their possibility of being functionalized with multiple copies of the drug molecule of interest. This review provids a concise discussion of nano carriers for drug transport across the intact BBB, various forms of nanomaterials including inorganic/solid lipid/polymeric nanoparticles, nanoemulsions, quantum dots, nanogels, liposomes, micelles, dendrimers, polymersomes and exosomes are critically evaluated, their mechanisms for drug transport across the BBB are reviewed, and the future directions of this area are fully discussed.

U2 - 10.1080/1061186X.2016.1184272

DO - 10.1080/1061186X.2016.1184272

M3 - Article

VL - 25

SP - 17

EP - 28

JO - Journal of Drug Targeting

JF - Journal of Drug Targeting

SN - 1061-186X

IS - 1

ER -

ID: 3957835