Oxidative damage in chronic heart failure: Prevention by captoril through free radical scavenging?
Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed)
The pathogenesis of heart failure is not yet fully understood. In animal models there is some evidence to suggest a role for free radicals (FRs). We have investigated malondialdehyde - LM in the plasma of patients with heart failure and found it to be raised when compared to controls. We present data to show that Captopril, a drug with an ACE inhibitory effect is a FR scavenger both in vitro and ex-vivo in patients with heart failure.
|Title of host publication||Antioxidants in Therapy and Preventive Medicine|
|Editors||Ingrid Emerit, Lester Packer, Christian Auclair|
|Publication status||Published - 1990|
|Name||Advances in Experimental Medicine and Biology|