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Oxidative damage in chronic heart failure: Prevention by captoril through free radical scavenging?

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review

  • Dr Mridula Chopra
  • John McMurray
  • John McLay
  • Alan Bridges
  • Norman Scott
  • Ewen W. Smith
  • Jill J. F. Belch
The pathogenesis of heart failure is not yet fully understood. In animal models there is some evidence to suggest a role for free radicals (FRs). We have investigated malondialdehyde - LM in the plasma of patients with heart failure and found it to be raised when compared to controls. We present data to show that Captopril, a drug with an ACE inhibitory effect is a FR scavenger both in vitro and ex-vivo in patients with heart failure.
Original languageEnglish
Title of host publicationAntioxidants in Therapy and Preventive Medicine
EditorsIngrid Emerit, Lester Packer, Christian Auclair
ISBN (Electronic)978-1-4684-5730-8
ISBN (Print)978-1-4684-5732-2
Publication statusPublished - 1990

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598

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