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Oxygen free radicals and congestive heart failure

Research output: Contribution to journalArticlepeer-review

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Oxygen free radicals and congestive heart failure. / Belch, Jill J. F.; Bridges, Alan B.; Scott, Norman; Chopra, Mridula.

In: British Heart Journal, Vol. 65, No. 5, 1991, p. 245-248.

Research output: Contribution to journalArticlepeer-review

Harvard

Belch, JJF, Bridges, AB, Scott, N & Chopra, M 1991, 'Oxygen free radicals and congestive heart failure', British Heart Journal, vol. 65, no. 5, pp. 245-248. https://doi.org/10.1136/hrt.65.5.245

APA

Belch, J. J. F., Bridges, A. B., Scott, N., & Chopra, M. (1991). Oxygen free radicals and congestive heart failure. British Heart Journal, 65(5), 245-248. https://doi.org/10.1136/hrt.65.5.245

Vancouver

Belch JJF, Bridges AB, Scott N, Chopra M. Oxygen free radicals and congestive heart failure. British Heart Journal. 1991;65(5):245-248. https://doi.org/10.1136/hrt.65.5.245

Author

Belch, Jill J. F. ; Bridges, Alan B. ; Scott, Norman ; Chopra, Mridula. / Oxygen free radicals and congestive heart failure. In: British Heart Journal. 1991 ; Vol. 65, No. 5. pp. 245-248.

Bibtex

@article{dd5a1ff74c814541a37675e58549bebb,
title = "Oxygen free radicals and congestive heart failure",
abstract = "Plasma lipid peroxides (malondialdehyde) and thiols were measured in 45 patients with congestive heart failure and 45 controls. Malondialdehyde concentrations were significantly higher in the patients with congestive heart failure (median 9.0 nmol/ml interquartile range (IQR) 7.9-10.2) than in the controls (median 7.7 nmol/ml (IQR 6.9-9.2)). Plasma thiols were significantly lower in congestive heart failure (median 420 mumol/l (IQR 379-480)) than in the controls (median 463 mumol/l (IQR 445-525)). There was a significant but weak negative correlation between malondialdehyde and left ventricular ejection fraction (r = -0.35) and a positive correlation between plasma thiols and left ventricular ejection fraction (r = 0.39). This study provides clinical support for experimental data indicating that free radicals may be important in heart failure. It also suggests that the degree of free radical production may be linked to the severity of the disease.",
author = "Belch, {Jill J. F.} and Bridges, {Alan B.} and Norman Scott and Mridula Chopra",
year = "1991",
doi = "10.1136/hrt.65.5.245",
language = "English",
volume = "65",
pages = "245--248",
journal = "British Heart Journal",
issn = "0007-0769",
publisher = "BMJ Publishing Group",
number = "5",

}

RIS

TY - JOUR

T1 - Oxygen free radicals and congestive heart failure

AU - Belch, Jill J. F.

AU - Bridges, Alan B.

AU - Scott, Norman

AU - Chopra, Mridula

PY - 1991

Y1 - 1991

N2 - Plasma lipid peroxides (malondialdehyde) and thiols were measured in 45 patients with congestive heart failure and 45 controls. Malondialdehyde concentrations were significantly higher in the patients with congestive heart failure (median 9.0 nmol/ml interquartile range (IQR) 7.9-10.2) than in the controls (median 7.7 nmol/ml (IQR 6.9-9.2)). Plasma thiols were significantly lower in congestive heart failure (median 420 mumol/l (IQR 379-480)) than in the controls (median 463 mumol/l (IQR 445-525)). There was a significant but weak negative correlation between malondialdehyde and left ventricular ejection fraction (r = -0.35) and a positive correlation between plasma thiols and left ventricular ejection fraction (r = 0.39). This study provides clinical support for experimental data indicating that free radicals may be important in heart failure. It also suggests that the degree of free radical production may be linked to the severity of the disease.

AB - Plasma lipid peroxides (malondialdehyde) and thiols were measured in 45 patients with congestive heart failure and 45 controls. Malondialdehyde concentrations were significantly higher in the patients with congestive heart failure (median 9.0 nmol/ml interquartile range (IQR) 7.9-10.2) than in the controls (median 7.7 nmol/ml (IQR 6.9-9.2)). Plasma thiols were significantly lower in congestive heart failure (median 420 mumol/l (IQR 379-480)) than in the controls (median 463 mumol/l (IQR 445-525)). There was a significant but weak negative correlation between malondialdehyde and left ventricular ejection fraction (r = -0.35) and a positive correlation between plasma thiols and left ventricular ejection fraction (r = 0.39). This study provides clinical support for experimental data indicating that free radicals may be important in heart failure. It also suggests that the degree of free radical production may be linked to the severity of the disease.

U2 - 10.1136/hrt.65.5.245

DO - 10.1136/hrt.65.5.245

M3 - Article

VL - 65

SP - 245

EP - 248

JO - British Heart Journal

JF - British Heart Journal

SN - 0007-0769

IS - 5

ER -

ID: 11653026