Polymer-lipid microparticles for pulmonary delivery
Research output: Contribution to journal › Article › peer-review
Towards engineering approaches that are designed to optimize the particle size, morphology and mucoadhesion behavior of the particulate component of inhaler formulations, this paper presents the preparation, physicochemical characterization and preliminary in vitro evaluation of multicomponent polymer-lipid systems that are based on “spray-drying engineered” α-lactose monohydrate microparticles. The formulations combine an active (budesonide) with a lung surfactant (dipalmitoylphosphatidylcholine) and with materials that are known for their desirable effects on morphology (polyvinyl-alcohol), aerosolization (L-leucine) and mucoadhesion (chitosan). The effect of the composition of formulations on the morphology, distribution and in vitro mucoadhesion profiles is presented along with “Calu-3 cell monolayers” data that indicate good cytocompatibility and also with simulated-lung-fluid data that are consistent with the therapeutically useful release of budesonide.
| Original language | English |
|---|---|
| Pages (from-to) | 3438-3448 |
| Number of pages | 11 |
| Journal | Langmuir |
| Volume | 34 |
| Issue number | 11 |
| Early online date | 27 Feb 2018 |
| DOIs | |
| Publication status | Published - 20 Mar 2018 |
Documents
- Polymer-lipid microparticles
Rights statement: This document is the Accepted Manuscript version of a Published Work that appeared in final form in Langmuir, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acs.langmuir.7b03645.
Accepted author manuscript (Post-print), 1.87 MB, PDF document
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