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Polymer-lipid microparticles for pulmonary delivery

Research output: Contribution to journalArticle

  • Georgios K. Eleftheriadis
  • Melpomeni Akrivou
  • Nikolaos Bouropoulos
  • Dr John Tsibouklis
  • Ioannis S Vizirianakis
  • Dimitrios G. Fatouros
Towards engineering approaches that are designed to optimize the particle size, morphology and mucoadhesion behavior of the particulate component of inhaler formulations, this paper presents the preparation, physicochemical characterization and preliminary in vitro evaluation of multicomponent polymer-lipid systems that are based on “spray-drying engineered” α-lactose monohydrate microparticles. The formulations combine an active (budesonide) with a lung surfactant (dipalmitoylphosphatidylcholine) and with materials that are known for their desirable effects on morphology (polyvinyl-alcohol), aerosolization (L-leucine) and mucoadhesion (chitosan). The effect of the composition of formulations on the morphology, distribution and in vitro mucoadhesion profiles is presented along with “Calu-3 cell monolayers” data that indicate good cytocompatibility and also with simulated-lung-fluid data that are consistent with the therapeutically useful release of budesonide.
Original languageEnglish
Pages (from-to)3438-3448
Number of pages11
JournalLangmuir
Volume34
Issue number11
Early online date27 Feb 2018
DOIs
Publication statusPublished - 20 Mar 2018

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  • Polymer-lipid microparticles

    Rights statement: This document is the Accepted Manuscript version of a Published Work that appeared in final form in Langmuir, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acs.langmuir.7b03645.

    Accepted author manuscript (Post-print), 1 MB, PDF document

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