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Prolonged skin retention of clobetasol propionate by bio-based microemulsions: a potential tool for scalp psoriasis treatment

Research output: Contribution to journalArticle

  • Rita Langasco
  • Sakine Tuncay Tanrıverdi
  • Özgen Özer
  • Dr Marta Roldo
  • Massimo Cossu
  • Giovanna Rassu
  • Paolo Giunchedi
  • Elisabetta Gavini
Novel effective and cosmetically acceptable formulations are needed for the treatment of scalp psoriasis, due to the poor efficacy of the current products. The challenge in developing safe, efficient, and convenient delivery systems for this drug was addressed in the present work by formulating clobetasol propionate-loaded W/O microemulsions (MEs). Pseudo-ternary phase diagrams were constructed by using a combination of biocompatible and biodegradable excipients. Characterization studies demonstrated that selected MEs had suitable technological features such as being Newtonian fluids, possessing low viscosity, and high thermodynamic stability. Photomicrographs showed a significant alteration of the skin structure after treatment with MEs, and a preferential concentration of these in the stratum corneum and epidermis. These data, together with ex vivo permeation results, suggested an enhanced topical targeted effect due to an increased drug retention efficacy in the upper skin layers, as desired. Moreover, the bio-based excipients selected could contribute to the healing of the psoriatic scalp. In this way, the improvement of clobetasol efficacy is combined with the useful properties of the microemulsion components and with environmental safety.
Original languageEnglish
JournalDrug Development and Industrial Pharmacy
Early online date8 Nov 2017
DOIs
StateEarly online - 8 Nov 2017

Documents

  • Prolonged skin retention of clobetasol

    Rights statement: This is an Accepted Manuscript of an article published by Taylor & Francis in Drug Development and Industrial Pharmacy on 08/11/2017, available online: http://www.tandfonline.com/10.1080/03639045.2017.1395458.

    Accepted author manuscript (Post-print), 1 MB, PDF-document

    Due to publisher’s copyright restrictions, this document is not freely available to download from this website until: 8/11/18

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