Risk of Malignancy (ROM) in the various categories of the UK Royal College of Pathologists thy terminology for thyroid FNAC cytology: a systematic review and meta-analysis
Research output: Contribution to journal › Article
Methods - A comprehensive literature search of online databases was conducted in May 2019 examining the ROM for histologically proven nodules with preoperative FNAC classified according to the UK Thy terminology.
Results - 25 articles were identified showing results of both cytology and histology. 12 of these were excluded to prevent selection bias as they showed data in just one Thy category. In the remaining 13 articles the pooled ROM was as follows; Thy 1: 12% (± 5-22%;95% CI); Thy 2: 5% (± 3-9%;95% CI); Thy 3: 22% (± 18-26%;95% CI); Thy 3a: 25% (± 20-31%;95% CI); Thy 3f: 31% (± 24-39%;95% CI); Thy 4: 79% (± 70-87%;95% CI); and Thy 5: 98% (± 97-99%; 95% CI) .
Conclusion - This meta-analysis shows comparable results to meta-analyses of other internationally recognised reporting terminologies for pooled risk of malignancy for surgically excised nodules in the various Thy reporting categories. There is comparatively little difference (6% only) between the pooled ROM of Thy 3a and Thy 3f surgically excised nodules.
|Number of pages||7|
|Early online date||13 Nov 2019|
|Publication status||Published - 1 Jan 2020|
- Risk of Malignancy
Rights statement: This is the peer reviewed version of the following article: Poller, D.N., Bongiovanni, M. and Trimboli, P. (2020), Risk of malignancy in the various categories of the UK Royal College of Pathologists Thy terminology for thyroid FNA cytology: A systematic review and meta‐analysis. Cancer Cytopathology, 128: 36-42, which has been published in final form at doi:10.1002/cncy.22201. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
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