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Strain transfer through the aortic valve

Research output: Contribution to journalArticlepeer-review

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Strain transfer through the aortic valve. / Anssari-benam, Afshin; Gupta, H.; Screen, H.

In: Journal of Biomechanical Engineering, Vol. 134, No. 6, 08.06.2012, p. 061003.

Research output: Contribution to journalArticlepeer-review

Harvard

Anssari-benam, A, Gupta, H & Screen, H 2012, 'Strain transfer through the aortic valve', Journal of Biomechanical Engineering, vol. 134, no. 6, pp. 061003. https://doi.org/10.1115/1.4006812

APA

Anssari-benam, A., Gupta, H., & Screen, H. (2012). Strain transfer through the aortic valve. Journal of Biomechanical Engineering, 134(6), 061003. https://doi.org/10.1115/1.4006812

Vancouver

Anssari-benam A, Gupta H, Screen H. Strain transfer through the aortic valve. Journal of Biomechanical Engineering. 2012 Jun 8;134(6):061003. https://doi.org/10.1115/1.4006812

Author

Anssari-benam, Afshin ; Gupta, H. ; Screen, H. / Strain transfer through the aortic valve. In: Journal of Biomechanical Engineering. 2012 ; Vol. 134, No. 6. pp. 061003.

Bibtex

@article{9f36949b431245f8beff0ad18c330cef,
title = "Strain transfer through the aortic valve",
abstract = "The complex structural organization of the aortic valve (AV) extracellular matrix (ECM) enables large and highly nonlinear tissue level deformations. The collagen and elastin (elastic) fibers within the ECM form an interconnected fibrous network (FN) and are known to be the main load-bearing elements of the AV matrix. The role of the FN in enabling deformation has been investigated and documented. However, there is little data on the correlation between tissue level and FN-level strains. Investigating this correlation will help establish the mode of strain transfer (affine or nonaffine) through the AV tissue as a key feature in microstructural modeling and will also help characterize the local FN deformation across the AV sample in response to applied tissue level strains. In this study, the correlation between applied strains at tissue level, macrostrains across the tissue surface, and local FN strains were investigated. Results showed that the FN strain distribution across AV samples was inhomogeneous and nonuniform, as well as anisotropic. There was no direct transfer of the deformation applied at tissue level to the fibrous network. Loading modes induced in the FN are different than those applied at the tissue as a result of different local strains in the valve layers. This nonuniformity of local strains induced internal shearing within the FN of the AV, possibly exposing the aortic valve interstitial cells (AVICs) to shear strains and stresses.",
author = "Afshin Anssari-benam and H. Gupta and H. Screen",
year = "2012",
month = jun,
day = "8",
doi = "10.1115/1.4006812",
language = "English",
volume = "134",
pages = "061003",
journal = "Journal of Biomechanical Engineering",
issn = "0148-0731",
publisher = "American Society of Mechanical Engineers(ASME)",
number = "6",

}

RIS

TY - JOUR

T1 - Strain transfer through the aortic valve

AU - Anssari-benam, Afshin

AU - Gupta, H.

AU - Screen, H.

PY - 2012/6/8

Y1 - 2012/6/8

N2 - The complex structural organization of the aortic valve (AV) extracellular matrix (ECM) enables large and highly nonlinear tissue level deformations. The collagen and elastin (elastic) fibers within the ECM form an interconnected fibrous network (FN) and are known to be the main load-bearing elements of the AV matrix. The role of the FN in enabling deformation has been investigated and documented. However, there is little data on the correlation between tissue level and FN-level strains. Investigating this correlation will help establish the mode of strain transfer (affine or nonaffine) through the AV tissue as a key feature in microstructural modeling and will also help characterize the local FN deformation across the AV sample in response to applied tissue level strains. In this study, the correlation between applied strains at tissue level, macrostrains across the tissue surface, and local FN strains were investigated. Results showed that the FN strain distribution across AV samples was inhomogeneous and nonuniform, as well as anisotropic. There was no direct transfer of the deformation applied at tissue level to the fibrous network. Loading modes induced in the FN are different than those applied at the tissue as a result of different local strains in the valve layers. This nonuniformity of local strains induced internal shearing within the FN of the AV, possibly exposing the aortic valve interstitial cells (AVICs) to shear strains and stresses.

AB - The complex structural organization of the aortic valve (AV) extracellular matrix (ECM) enables large and highly nonlinear tissue level deformations. The collagen and elastin (elastic) fibers within the ECM form an interconnected fibrous network (FN) and are known to be the main load-bearing elements of the AV matrix. The role of the FN in enabling deformation has been investigated and documented. However, there is little data on the correlation between tissue level and FN-level strains. Investigating this correlation will help establish the mode of strain transfer (affine or nonaffine) through the AV tissue as a key feature in microstructural modeling and will also help characterize the local FN deformation across the AV sample in response to applied tissue level strains. In this study, the correlation between applied strains at tissue level, macrostrains across the tissue surface, and local FN strains were investigated. Results showed that the FN strain distribution across AV samples was inhomogeneous and nonuniform, as well as anisotropic. There was no direct transfer of the deformation applied at tissue level to the fibrous network. Loading modes induced in the FN are different than those applied at the tissue as a result of different local strains in the valve layers. This nonuniformity of local strains induced internal shearing within the FN of the AV, possibly exposing the aortic valve interstitial cells (AVICs) to shear strains and stresses.

U2 - 10.1115/1.4006812

DO - 10.1115/1.4006812

M3 - Article

VL - 134

SP - 061003

JO - Journal of Biomechanical Engineering

JF - Journal of Biomechanical Engineering

SN - 0148-0731

IS - 6

ER -

ID: 250297