The effects of aerobic and resistance exercise on markers of large joint health in stable rheumatoid arthritis patients: a pilot study
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Methods - Eight RA patients and eight healthy, matched control (CTL) participants performed 30 minutes’ high-intensity, low-impact aerobic and lower-body resistance exercise, one week apart. Primary outcome measures assessing joint health were serum cartilage oligomeric matrix protein (sCOMP) and knee joint synovial inflammation (Doppler ultrasound colour fraction; CF). These measures were taken at baseline, immediately after and 0.5, one, two, six and 24 hours post-exercise. In a separate study, nine RA patients completed eight weeks of progressive exercise training. The same outcome measures were reassessed at baseline, and at one hour post-exercise of training weeks 0, 1, 4 and 8.
Results - RA patients showed higher overall sCOMP [RA: 1,347 ± 421, CTL: 1,189 ± 562 ng/mL; p < 0.05; effect size (ES) = 0.32] and CF when scanned longitudinally (RA: 0.489 ± 0.30 × 10–3, CTL: 0.101 ± 0.13 × 10–3; p < 0.01; ES = 1.73) and transversely (RA: 0.938 ± 0.69 × 10–3, CTL: 0.199 ± 0.36 × 10–3; p < 0.01; ES = 1.33) than CTL. However, no acute effects on joint health were observed post-exercise. Similarly, no chronic effects were observed over eight weeks of combined aerobic and resistance training in RA, with positive effects on physical fitness and function.
Conclusions - RA patients on stable treatment with low disease activity were able to perform an individually prescribed high-intensity, low-impact aerobic and resistance exercise without changes in markers of large joint health.
|Early online date||12 May 2015|
|Publication status||Published - Dec 2015|
- The effects of aerobic and resistance exercise
Rights statement: This is the peer reviewed version of the following article: Law, R.-J., Saynor, Z. L., Gabbitas, J., Jones, J., Kraus, A., Breslin, A., Maddison, P. J., and Thom, J. M. (2015), The Effects of Aerobic and Resistance Exercise on Markers of Large Joint Health in Stable Rheumatoid Arthritis Patients: A Pilot Study. Musculoskelet. Care, doi: 10.1002/msc.1103., which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/msc.1103/full. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Accepted author manuscript (Post-print), 435 KB, PDF document