Skip to content

The effects of two stressors on working memory and cognitive flexibility in zebrafish (Danio rerio): the protective role of D1/D5 agonist on stress responses

Research output: Contribution to journalArticlepeer-review

Acute stressors are recurrent in multiple species' lives and can facilitate or impair cognition. The use of zebrafish (Danio rerio) as a translational species to understand the mechanisms by which stress induces different behavioral phenotypes has been widely studied. Two acute stressors are recognized when using this species: (1) conspecific alarm substance (CAS); and (2) net chasing. Here, we tested if CAS or net chasing would affect working memory and cognitive flexibility by testing performance in the FMP Y-maze after exposure to stress. We observed that CAS altered zebrafish behavioral phenotypes by increasing repetitive behavior; meanwhile, animals showed different patterns of repetitive behavior when exposed to net chasing, depending on the chasing direction. Because D1 receptors were previously studied as a potential mechanism underlying stress responses in different species, here, we pretreated fish with a D1/D5 agonist (SKF-38393) to assess whether this system plays a role in repetitive behavior in the FMP Y-maze. The pretreatment with D1/D5 agonist significantly decreased repetitive behavior in CAS exposed animals, and cortisol levels for both stressed groups, suggesting that the dopaminergic system plays an important role in zebrafish stress-related responses.
Original languageEnglish
Article number108681
Number of pages10
JournalNeuropharmacology
Volume196
Early online date24 Jun 2021
DOIs
Publication statusEarly online - 24 Jun 2021

Documents

  • The effects of two stressors

    Accepted author manuscript (Post-print), 1.04 MB, PDF document

    Due to publisher’s copyright restrictions, this document is not freely available to download from this website until: 24/06/22

    Licence: CC BY-NC-ND

Related information

Relations Get citation (various referencing formats)

ID: 28709810