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The factors affecting liquid and semi-solid mucoadhesion to the oral cavity and oesophagus

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  • Simon A. Young
  • Brian Carpenter
  • T. Nevell
  • J. Smart
Liquid and semi-solid formulations adherent to the mouth, pharynx and oesophagus may provide mechanical protection, palliative relief and treat local disease. These mucosae also offer a substantial area of well-perfused tissue, perhaps suitable for systemic drug delivery. However, successful formulation design has been curtailed by the lack of a generally accepted method for evaluating mucoadhesive performance. Moreover, the mucoadhesive interaction is a complex phenomenon rather than a single-process bond. Therefore, an understanding of the relationship between mucoadhesive performance and the physicochemical properties must be elucidated to allow rational design of retentive dosage forms.
Original languageEnglish
Pages (from-to)22
Number of pages1
JournalJournal of Pharmacy and Pharmacology
Issue numberS1
Publication statusPublished - 2002

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