The formulation of polyhedral boranes for the boron neutron capture therapy of cancer
Research output: Contribution to journal › Article
The early promise of boron neutron capture therapy as a method for the treatment of cancer has been inhibited by the inherent toxicity associated with therapeutically useful doses of 10B-containing pharmacophores, the need for target-tissue specificity and the challenges imposed by biological barriers. Although developments in the synthetic chemistry of polyhedral boranes have addressed issues of toxicity to a considerable extent, the optimisation of the transport and the delivery of boronated agents to the site of action – the subject of this review – is a challenge that is addressed by the development of innovative formulation strategies.
|Number of pages||7|
|Journal||Drug Discovery Today|
|Publication status||Published - Feb 2012|