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The formulation of polyhedral boranes for the boron neutron capture therapy of cancer

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The early promise of boron neutron capture therapy as a method for the treatment of cancer has been inhibited by the inherent toxicity associated with therapeutically useful doses of 10B-containing pharmacophores, the need for target-tissue specificity and the challenges imposed by biological barriers. Although developments in the synthetic chemistry of polyhedral boranes have addressed issues of toxicity to a considerable extent, the optimisation of the transport and the delivery of boronated agents to the site of action – the subject of this review – is a challenge that is addressed by the development of innovative formulation strategies.
Original languageEnglish
Pages (from-to)153-159
Number of pages7
JournalDrug Discovery Today
Issue number3-4
Publication statusPublished - Feb 2012

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