Skip to content

The impact of plasma 25‐hydroxyvitamin D on pulmonary function and exercise physiology in cystic fibrosis: a multicentre retrospective study

Research output: Contribution to journalArticlepeer-review

  • Raquel Revuelta Iniesta
  • Adam John Causer
  • Irantzu Arregui-Fresneda
  • Gary Connett
  • Mark I. Allenby
  • Thomas Daniels
  • Mary P. Carroll
  • Don S. Urquhart
  • Dr Zoe Saynor
Background: 25‐hydroxyvitamin D (25OHD) may exert immunomodulatory effects on respiratory health, which may translate to improvements in exercise physiology. Thus, we aimed to investigate whether plasma 25OHD is associated with lung function and aerobic fitness in people with cystic fibrosis (pwCF).

Methods: A multi‐centre retrospective review of pwCF (>9 years old) attending the Royal Hospital for Sick Children (Edinburgh) or Wessex CF‐Unit (Southampton) was performed between July 2017 to October 2019. Demographic and clinical data were collected. Plasma 25OHD measured closest in time to clinical cardiopulmonary exercise testing (CPET) and/or spirometry (forced expiratory volume FEV1% predicted) was recorded. Pancreatic insufficiency was diagnosed based on faecal elastase of <100 µg/g. We performed multiple‐regression analysis with aerobic fitness outcomes [peak oxygen uptake (VO2peak)] and FEV1% predicted as primary outcomes.

Results: Ninety pwCF [mean±SD age: 19.1±8.6 years, 54 (60%) children, 48 (53%) males and 88 (98%) Caucasian] were included. 25OHD deficiency and insufficiency was 15 (17%) and 44 (49%) respectively. 25OHD deficiency and insufficiency was significantly associated with pancreatic insufficiency (χ2(4.8); p = 0.02). Plasma 25OHD was not significantly associated with FEV1% predicted [R2 = 0.06; p= 0.42; 95%; CI (‐0.09 ‐ 0.19)] or VO2peak [R2= 0.04; p= 0.07; 95% CI (‐011 ‐ 0.005)] in all pwCF. However, 25OHD was significantly associated with both FEV1% [R2= 0.15; p= 0.02; 95% CI (1.99 ‐ 2.64)] and VO2peak [R2= 0.13; p= 0.05; 95% CI (‐0.26 – (‐0.005)] in the paediatric cohort.

Conclusion: We showed that 25OHD is associated with improved lung function and aerobic fitness in children and adolescents with CF. Mechanistic and high‐quality prospective studies including both lung function and aerobic fitness as primary outcomes are now warranted.
Original languageEnglish
JournalJournal of Human Nutrition & Dietetics
Publication statusAccepted for publication - 21 Apr 2021


  • The impact of plasma 25-hydroxyvitamin D

    Rights statement: The embargo end date of 2050 is a temporary measure until we know the publication date. Once we know the publication date the full text of this article will be able to view shortly afterwards.

    Accepted author manuscript (Post-print), 13.4 MB, PDF document

    Due to publisher’s copyright restrictions, this document is not freely available to download from this website until: 1/01/50

Related information

Relations Get citation (various referencing formats)

ID: 27364867