The oxygen uptake efficiency slope is not a valid surrogate of aerobic fitness in cystic fibrosis
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Methods - Data were collated from 72 cardiopulmonary exercise tests (36 CF, 36 controls), with OUES determined relative to maximal and submaximal parameters of exercise intensity, time and individual metabolic thresholds. Pearson’s correlation coefficients, independent t-tests and factorial ANOVAs were used to determine validity.
Results - Significant (p < 0.05) correlations with V̇O2max were observed for most expressions of OUES, but were consistently weaker in CF (r = 0.30 – 0.47) when compared to CON (r = 0.58 – 0.89). Mean differences for all OUES parameters between groups were not significant (p > 0.05). When split by V̇O2max tertiles, minimal significant differences were found between, and within, groups for OUES, indicating poor discrimination of V̇O2max.
Conclusions - The OUES is not a valid (sub)maximal measure of V̇O2max in children and adolescents with mild-to-moderate CF. Clinicians should continue to use maximal markers (i.e. V̇O2max) of exercise capacity.
|Number of pages||7|
|Early online date||24 Oct 2017|
|Publication status||Published - 1 Jan 2018|
- The oxygen update efficiency slope
Rights statement: This is the peer reviewed version of the following article: Williams CA, Tomlinson OW, Chubbock LV, et al. The oxygen uptake efficiency slope is not a valid surrogate of aerobic fitness in cystic fibrosis. Pediatr Pulmonol. 2017; 1–7. https://doi.org/10.1002/ppul.23896, which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/ppul.23896/full. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
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