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The retention of 14C-labelled poly(acrylic acids) on gastric and oesophageal mucosa: An in vitro study

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The retention of 14C-labelled poly(acrylic acids) on gastric and oesophageal mucosa : An in vitro study. / Smart, John D.; Riley, Robert G.; Tsibouklis, John; Young, Simon A.; Hampson, Frank C.; Davis, J. Alf; Kelly, Grant; Dettmar, Peter W.; Wilber, William R.

In: European Journal of Pharmaceutical Sciences, Vol. 20, No. 1, 01.01.2003, p. 83-90.

Research output: Contribution to journalArticle

Harvard

Smart, JD, Riley, RG, Tsibouklis, J, Young, SA, Hampson, FC, Davis, JA, Kelly, G, Dettmar, PW & Wilber, WR 2003, 'The retention of 14C-labelled poly(acrylic acids) on gastric and oesophageal mucosa: An in vitro study', European Journal of Pharmaceutical Sciences, vol. 20, no. 1, pp. 83-90. https://doi.org/10.1016/S0928-0987(03)00175-1

APA

Smart, J. D., Riley, R. G., Tsibouklis, J., Young, S. A., Hampson, F. C., Davis, J. A., ... Wilber, W. R. (2003). The retention of 14C-labelled poly(acrylic acids) on gastric and oesophageal mucosa: An in vitro study. European Journal of Pharmaceutical Sciences, 20(1), 83-90. https://doi.org/10.1016/S0928-0987(03)00175-1

Vancouver

Smart JD, Riley RG, Tsibouklis J, Young SA, Hampson FC, Davis JA et al. The retention of 14C-labelled poly(acrylic acids) on gastric and oesophageal mucosa: An in vitro study. European Journal of Pharmaceutical Sciences. 2003 Jan 1;20(1):83-90. https://doi.org/10.1016/S0928-0987(03)00175-1

Author

Smart, John D. ; Riley, Robert G. ; Tsibouklis, John ; Young, Simon A. ; Hampson, Frank C. ; Davis, J. Alf ; Kelly, Grant ; Dettmar, Peter W. ; Wilber, William R. / The retention of 14C-labelled poly(acrylic acids) on gastric and oesophageal mucosa : An in vitro study. In: European Journal of Pharmaceutical Sciences. 2003 ; Vol. 20, No. 1. pp. 83-90.

Bibtex

@article{4954bc3b8f864cef85a442b238c7d73a,
title = "The retention of 14C-labelled poly(acrylic acids) on gastric and oesophageal mucosa: An in vitro study",
abstract = "Polymers that bind from solution onto gastric mucosa can be used either as a means of facilitating localised drug delivery, or can act as therapeutic agents in their own right (e.g. by forming a protective layer or by inhibiting enzymes). In our previous study [Int. J. Pharm. 236 (2002) 87], the binding and retention of labelled poly(acrylic acid)s on sections of gastric mucosa from pigs was evaluated using 'dynamic flow' conditions and a high molecular weight poly(acrylic acid) was found to bind most avidly. In the current study, 3{\%} solutions of 'low', 'high' and 'ultra high' molecular weight polymers were evaluated in the 'dynamic flow' model for their ability to bind to tissues from the fundic and pyloric regions of the stomach and the oesophagus of pigs. All the polymers tested were retained on each mucosa for extended periods; the high and ultra high molecular weight polymers showed the greatest retention. Examination of the kinetics of polymer elution suggested that two fractions exist, 'bound' and 'unbound' polymer, showing differing retention profiles. The high molecular weight polymer showed the greatest retention on pyloric tissue, particularly on the upper sections. The retention of the ultra high and high molecular weight polymer was similar on the fundic and oesophageal mucosa, and the distribution was even across the tissue. It was concluded that poly(acrylic acid) binding from solution presents a therapeutic opportunity, and the differences in binding and retention of the polymers on the different mucosae could present an opportunity for targeting.",
keywords = "Bioadhesion, Gastric mucosa, Mucoadhesion, Oesophagus, Poly(acrylic acid)",
author = "Smart, {John D.} and Riley, {Robert G.} and John Tsibouklis and Young, {Simon A.} and Hampson, {Frank C.} and Davis, {J. Alf} and Grant Kelly and Dettmar, {Peter W.} and Wilber, {William R.}",
year = "2003",
month = "1",
day = "1",
doi = "10.1016/S0928-0987(03)00175-1",
language = "English",
volume = "20",
pages = "83--90",
journal = "European Journal of Pharmaceutical Sciences",
issn = "0928-0987",
publisher = "Elsevier",
number = "1",

}

RIS

TY - JOUR

T1 - The retention of 14C-labelled poly(acrylic acids) on gastric and oesophageal mucosa

T2 - An in vitro study

AU - Smart, John D.

AU - Riley, Robert G.

AU - Tsibouklis, John

AU - Young, Simon A.

AU - Hampson, Frank C.

AU - Davis, J. Alf

AU - Kelly, Grant

AU - Dettmar, Peter W.

AU - Wilber, William R.

PY - 2003/1/1

Y1 - 2003/1/1

N2 - Polymers that bind from solution onto gastric mucosa can be used either as a means of facilitating localised drug delivery, or can act as therapeutic agents in their own right (e.g. by forming a protective layer or by inhibiting enzymes). In our previous study [Int. J. Pharm. 236 (2002) 87], the binding and retention of labelled poly(acrylic acid)s on sections of gastric mucosa from pigs was evaluated using 'dynamic flow' conditions and a high molecular weight poly(acrylic acid) was found to bind most avidly. In the current study, 3% solutions of 'low', 'high' and 'ultra high' molecular weight polymers were evaluated in the 'dynamic flow' model for their ability to bind to tissues from the fundic and pyloric regions of the stomach and the oesophagus of pigs. All the polymers tested were retained on each mucosa for extended periods; the high and ultra high molecular weight polymers showed the greatest retention. Examination of the kinetics of polymer elution suggested that two fractions exist, 'bound' and 'unbound' polymer, showing differing retention profiles. The high molecular weight polymer showed the greatest retention on pyloric tissue, particularly on the upper sections. The retention of the ultra high and high molecular weight polymer was similar on the fundic and oesophageal mucosa, and the distribution was even across the tissue. It was concluded that poly(acrylic acid) binding from solution presents a therapeutic opportunity, and the differences in binding and retention of the polymers on the different mucosae could present an opportunity for targeting.

AB - Polymers that bind from solution onto gastric mucosa can be used either as a means of facilitating localised drug delivery, or can act as therapeutic agents in their own right (e.g. by forming a protective layer or by inhibiting enzymes). In our previous study [Int. J. Pharm. 236 (2002) 87], the binding and retention of labelled poly(acrylic acid)s on sections of gastric mucosa from pigs was evaluated using 'dynamic flow' conditions and a high molecular weight poly(acrylic acid) was found to bind most avidly. In the current study, 3% solutions of 'low', 'high' and 'ultra high' molecular weight polymers were evaluated in the 'dynamic flow' model for their ability to bind to tissues from the fundic and pyloric regions of the stomach and the oesophagus of pigs. All the polymers tested were retained on each mucosa for extended periods; the high and ultra high molecular weight polymers showed the greatest retention. Examination of the kinetics of polymer elution suggested that two fractions exist, 'bound' and 'unbound' polymer, showing differing retention profiles. The high molecular weight polymer showed the greatest retention on pyloric tissue, particularly on the upper sections. The retention of the ultra high and high molecular weight polymer was similar on the fundic and oesophageal mucosa, and the distribution was even across the tissue. It was concluded that poly(acrylic acid) binding from solution presents a therapeutic opportunity, and the differences in binding and retention of the polymers on the different mucosae could present an opportunity for targeting.

KW - Bioadhesion

KW - Gastric mucosa

KW - Mucoadhesion

KW - Oesophagus

KW - Poly(acrylic acid)

UR - http://www.scopus.com/inward/record.url?scp=0041331757&partnerID=8YFLogxK

U2 - 10.1016/S0928-0987(03)00175-1

DO - 10.1016/S0928-0987(03)00175-1

M3 - Article

C2 - 13678796

AN - SCOPUS:0041331757

VL - 20

SP - 83

EP - 90

JO - European Journal of Pharmaceutical Sciences

JF - European Journal of Pharmaceutical Sciences

SN - 0928-0987

IS - 1

ER -

ID: 11419536