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Toward drug delivery into the brain: synthesis, characterization, and preliminary in vitro assessment of alkylglyceryl-functionalized chitosan nanoparticles

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Toward drug delivery into the brain: synthesis, characterization, and preliminary in vitro assessment of alkylglyceryl-functionalized chitosan nanoparticles. / Molnar, E.; Barbu, Eugen; Lien, Chun; Gorecki, Darek; Tsibouklis, John.

In: Biomacromolecules, Vol. 11, No. 11, 2010, p. 2880-2889.

Research output: Contribution to journalArticlepeer-review

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@article{8202120a64d34567a0188110dab8d1a9,
title = "Toward drug delivery into the brain: synthesis, characterization, and preliminary in vitro assessment of alkylglyceryl-functionalized chitosan nanoparticles",
abstract = "A series of O-substituted alkylglyceryl chitosans with systematically varied degrees of grafting was prepared through synthetic steps that involved the protection of amino moieties via phthaloylation and employed for the formulation of aqueous nanoparticulate systems that may be capable of delivering drugs to the brain. Dynamic light scattering studies have shown that nanoparticles with physiologically relevant aqueous stabilities may be prepared following the partial quaternization of these alkylglyceryl-modified chitosans. Preliminary in vitro tests using a mouse-brain endothelial cell model have indicated the efficient cellular uptake of these nanoparticles and identified butylglyceryl chitosan and butylglyceryl N,N,N-trimethyl chitosan as promising materials for the formulation of colloidal systems that could act as drug carriers into the brain.",
author = "E. Molnar and Eugen Barbu and Chun Lien and Darek Gorecki and John Tsibouklis",
year = "2010",
doi = "10.1021/bm100577x",
language = "English",
volume = "11",
pages = "2880--2889",
journal = "Biomacromolecules",
issn = "1525-7797",
publisher = "American Chemical Society",
number = "11",

}

RIS

TY - JOUR

T1 - Toward drug delivery into the brain: synthesis, characterization, and preliminary in vitro assessment of alkylglyceryl-functionalized chitosan nanoparticles

AU - Molnar, E.

AU - Barbu, Eugen

AU - Lien, Chun

AU - Gorecki, Darek

AU - Tsibouklis, John

PY - 2010

Y1 - 2010

N2 - A series of O-substituted alkylglyceryl chitosans with systematically varied degrees of grafting was prepared through synthetic steps that involved the protection of amino moieties via phthaloylation and employed for the formulation of aqueous nanoparticulate systems that may be capable of delivering drugs to the brain. Dynamic light scattering studies have shown that nanoparticles with physiologically relevant aqueous stabilities may be prepared following the partial quaternization of these alkylglyceryl-modified chitosans. Preliminary in vitro tests using a mouse-brain endothelial cell model have indicated the efficient cellular uptake of these nanoparticles and identified butylglyceryl chitosan and butylglyceryl N,N,N-trimethyl chitosan as promising materials for the formulation of colloidal systems that could act as drug carriers into the brain.

AB - A series of O-substituted alkylglyceryl chitosans with systematically varied degrees of grafting was prepared through synthetic steps that involved the protection of amino moieties via phthaloylation and employed for the formulation of aqueous nanoparticulate systems that may be capable of delivering drugs to the brain. Dynamic light scattering studies have shown that nanoparticles with physiologically relevant aqueous stabilities may be prepared following the partial quaternization of these alkylglyceryl-modified chitosans. Preliminary in vitro tests using a mouse-brain endothelial cell model have indicated the efficient cellular uptake of these nanoparticles and identified butylglyceryl chitosan and butylglyceryl N,N,N-trimethyl chitosan as promising materials for the formulation of colloidal systems that could act as drug carriers into the brain.

U2 - 10.1021/bm100577x

DO - 10.1021/bm100577x

M3 - Article

VL - 11

SP - 2880

EP - 2889

JO - Biomacromolecules

JF - Biomacromolecules

SN - 1525-7797

IS - 11

ER -

ID: 63126