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Towards boron neutron capture therapy: the formulation and preliminary in vitro evaluation of liposomal vehicles for the delivery of the dequalinium salt of bis-nido-carborane

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Liposomes of phosphatidylcholine or of dimyristoylphosphatidylcholine that incorporate bis-nido-carborane dequalinium salt are stable in physiologically relevant media and have in vitro toxicity profiles that appear to be compatible with potential therapeutic applications. These features render the structures suitable candidate boron-delivery vehicles for evaluation in the Boron Neutron Capture Therapy of cancer.
Original languageEnglish
Pages (from-to)6161-6166
JournalBioorganic & Medicinal Chemistry Letters
Issue number22
Early online date9 Sep 2013
Publication statusPublished - 15 Nov 2013

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