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Transcutaneous anaesthetic nano-enabled hydrogels for eyelid surgery

Research output: Contribution to journalArticle

Standard

Transcutaneous anaesthetic nano-enabled hydrogels for eyelid surgery. / Lalatsa, Katerina; Patel, Priyanka V; Sun, Yujiao; Kiun, Chong C; Karimi, Ferishtah; Zekonyte, Jurgita; Emeriewen, Krisztina; Saleh, George M.

In: International Journal of Pharmaceutics, Vol. 577, 119003, 15.03.2020.

Research output: Contribution to journalArticle

Harvard

Lalatsa, K, Patel, PV, Sun, Y, Kiun, CC, Karimi, F, Zekonyte, J, Emeriewen, K & Saleh, GM 2020, 'Transcutaneous anaesthetic nano-enabled hydrogels for eyelid surgery', International Journal of Pharmaceutics, vol. 577, 119003. https://doi.org/10.1016/j.ijpharm.2019.119003

APA

Lalatsa, K., Patel, P. V., Sun, Y., Kiun, C. C., Karimi, F., Zekonyte, J., Emeriewen, K., & Saleh, G. M. (2020). Transcutaneous anaesthetic nano-enabled hydrogels for eyelid surgery. International Journal of Pharmaceutics, 577, [119003]. https://doi.org/10.1016/j.ijpharm.2019.119003

Vancouver

Lalatsa K, Patel PV, Sun Y, Kiun CC, Karimi F, Zekonyte J et al. Transcutaneous anaesthetic nano-enabled hydrogels for eyelid surgery. International Journal of Pharmaceutics. 2020 Mar 15;577. 119003. https://doi.org/10.1016/j.ijpharm.2019.119003

Author

Lalatsa, Katerina ; Patel, Priyanka V ; Sun, Yujiao ; Kiun, Chong C ; Karimi, Ferishtah ; Zekonyte, Jurgita ; Emeriewen, Krisztina ; Saleh, George M. / Transcutaneous anaesthetic nano-enabled hydrogels for eyelid surgery. In: International Journal of Pharmaceutics. 2020 ; Vol. 577.

Bibtex

@article{8ff1f2e2ad2b4172901eec46e0167f1a,
title = "Transcutaneous anaesthetic nano-enabled hydrogels for eyelid surgery",
abstract = "Local anaesthetics are administered as a diffuse superficial slow injection in blepharoplasty. Current transcutaneous local anaesthetic formulations are not licensed for use on the face due to safety concerns. Here we report for the first time the permeation of local anaesthetics (lidocaine, bupivacaine loaded SNEDDS and their hydrogels across human eyelid and mouse skin as a novel and ocular safe formulation for eyelid surgery. SNEDDS were loaded with high levels of anaesthetics and incorporated within carbomer hydrogels to yield nano-enabled gels. Lidocaine hydrogels have a significantly reduced lag time compared to EMLA, while they enhance lidocaine flux across human eyelid skin by 5.2 fold. Ex vivo tape stripping experiments indicated localisation of anaesthetics within the stratum corneum and dermis. Initial histopathological studies have shown no apparent signs of skin irritation. These results highlight the potential clinical capability of nano-enabled anaesthetic hydrogels as a non-invasive anaesthetic procedure for eyelid surgery. ",
keywords = "Lidocaine, Bupivacaine, Anaesthetics, Self-nanoemulsifying drug delivery systems (SNEDDS), hydrogels, eyelid, tape stripping, Franz cell diffusion assays",
author = "Katerina Lalatsa and Patel, {Priyanka V} and Yujiao Sun and Kiun, {Chong C} and Ferishtah Karimi and Jurgita Zekonyte and Krisztina Emeriewen and Saleh, {George M.}",
year = "2020",
month = mar,
day = "15",
doi = "10.1016/j.ijpharm.2019.119003",
language = "English",
volume = "577",
journal = "International Journal of Pharmaceutics",
issn = "0378-5173",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Transcutaneous anaesthetic nano-enabled hydrogels for eyelid surgery

AU - Lalatsa, Katerina

AU - Patel, Priyanka V

AU - Sun, Yujiao

AU - Kiun, Chong C

AU - Karimi, Ferishtah

AU - Zekonyte, Jurgita

AU - Emeriewen, Krisztina

AU - Saleh, George M.

PY - 2020/3/15

Y1 - 2020/3/15

N2 - Local anaesthetics are administered as a diffuse superficial slow injection in blepharoplasty. Current transcutaneous local anaesthetic formulations are not licensed for use on the face due to safety concerns. Here we report for the first time the permeation of local anaesthetics (lidocaine, bupivacaine loaded SNEDDS and their hydrogels across human eyelid and mouse skin as a novel and ocular safe formulation for eyelid surgery. SNEDDS were loaded with high levels of anaesthetics and incorporated within carbomer hydrogels to yield nano-enabled gels. Lidocaine hydrogels have a significantly reduced lag time compared to EMLA, while they enhance lidocaine flux across human eyelid skin by 5.2 fold. Ex vivo tape stripping experiments indicated localisation of anaesthetics within the stratum corneum and dermis. Initial histopathological studies have shown no apparent signs of skin irritation. These results highlight the potential clinical capability of nano-enabled anaesthetic hydrogels as a non-invasive anaesthetic procedure for eyelid surgery.

AB - Local anaesthetics are administered as a diffuse superficial slow injection in blepharoplasty. Current transcutaneous local anaesthetic formulations are not licensed for use on the face due to safety concerns. Here we report for the first time the permeation of local anaesthetics (lidocaine, bupivacaine loaded SNEDDS and their hydrogels across human eyelid and mouse skin as a novel and ocular safe formulation for eyelid surgery. SNEDDS were loaded with high levels of anaesthetics and incorporated within carbomer hydrogels to yield nano-enabled gels. Lidocaine hydrogels have a significantly reduced lag time compared to EMLA, while they enhance lidocaine flux across human eyelid skin by 5.2 fold. Ex vivo tape stripping experiments indicated localisation of anaesthetics within the stratum corneum and dermis. Initial histopathological studies have shown no apparent signs of skin irritation. These results highlight the potential clinical capability of nano-enabled anaesthetic hydrogels as a non-invasive anaesthetic procedure for eyelid surgery.

KW - Lidocaine

KW - Bupivacaine

KW - Anaesthetics

KW - Self-nanoemulsifying drug delivery systems (SNEDDS)

KW - hydrogels

KW - eyelid

KW - tape stripping

KW - Franz cell diffusion assays

U2 - 10.1016/j.ijpharm.2019.119003

DO - 10.1016/j.ijpharm.2019.119003

M3 - Article

VL - 577

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

M1 - 119003

ER -

ID: 15421585