Two are better than one
Research output: Contribution to journal › Article › peer-review
A crystal structure of a tetrameric restriction enzyme, NgoMIV, bound to two DNA duplexes has been determined. Two subunits contact each duplex in much the same manner as a dimeric restriction enzyme recognizing a single site, but the dimeric units are packed back-to-back, placing the duplexes on opposite sides of the tetramer. Interaction with two recognition sites, presumably via looping, enhances NgoMIV activity.
|Number of pages||3|
|Journal||Nature Structural Biology|
|Publication status||Published - 2000|