Understanding the reactivity of acyl anion equivalents: the epoxide ring opening case
Research output: Contribution to journal › Article › peer-review
Acyl anion equivalents (umpolung) are the practitioner's first choice en route to 1,3-hydroxy keto compounds from epoxides. Why? This investigation evaluates computationally and experimentally the reactivity of a near comprehensive range of acyl anion equivalents using epoxide ring opening as a test vehicle. Reactivity understanding, reactivity order, surprise failures in performance, along with unprecedented, but far from superior, reactivity of TosMIC is presented for the first time.
|Number of pages||6|
|Journal||European Journal of Organic Chemistry|
|Publication status||Published - May 2011|