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Using Small angle X-ray acattering (SAXS) to characterise the solution conformation and flexibility of matrix metalloproteinases (MMPs)

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review

Small angle X-ray scattering (SAXS) provides information about the conformation and flexibility of proteins in solution, and hence provides complementary structural information to that obtained from X-ray crystallography and nuclear magnetic resonance spectroscopy. In this chapter, we describe the methods for the preparation of matrix metalloproteinase (MMP) samples for SAXS analyses, and for the acquisition, processing and interpretation of the SAXS data.
Original languageEnglish
Title of host publicationMatrix metalloproteases
Subtitle of host publicationmethods and protocols
EditorsCharles Galea
PublisherHumana Press
Number of pages22
ISBN (Electronic)978-1493968633
ISBN (Print)978-1493968619
Publication statusPublished - 16 Mar 2017

Publication series

NameMethods in Molecular Biology
ISSN (Print)1064-3745

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