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Using zebrafish (Danio rerio) models to understand the critical role of social interactions in mental health and wellbeing

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Using zebrafish (Danio rerio) models to understand the critical role of social interactions in mental health and wellbeing. / Fontana, Barbara D.; Müller, Talise E.; Cleal, Madeleine; De Abreu, Murilo S.; Norton, William H.J.; Demin, Konstantin A.; Amstislavskaya, Tamara G.; Petersen, Elena V.; Kalueff, Allan V.; Parker, Matthew O.; Rosemberg, Denis B.

In: Progress in Neurobiology, 10.01.2021.

Research output: Contribution to journalArticlepeer-review

Harvard

Fontana, BD, Müller, TE, Cleal, M, De Abreu, MS, Norton, WHJ, Demin, KA, Amstislavskaya, TG, Petersen, EV, Kalueff, AV, Parker, MO & Rosemberg, DB 2021, 'Using zebrafish (Danio rerio) models to understand the critical role of social interactions in mental health and wellbeing', Progress in Neurobiology. https://doi.org/10.1016/j.pneurobio.2021.101993

APA

Fontana, B. D., Müller, T. E., Cleal, M., De Abreu, M. S., Norton, W. H. J., Demin, K. A., Amstislavskaya, T. G., Petersen, E. V., Kalueff, A. V., Parker, M. O., & Rosemberg, D. B. (2021). Using zebrafish (Danio rerio) models to understand the critical role of social interactions in mental health and wellbeing. Progress in Neurobiology, [101993]. https://doi.org/10.1016/j.pneurobio.2021.101993

Vancouver

Author

Fontana, Barbara D. ; Müller, Talise E. ; Cleal, Madeleine ; De Abreu, Murilo S. ; Norton, William H.J. ; Demin, Konstantin A. ; Amstislavskaya, Tamara G. ; Petersen, Elena V. ; Kalueff, Allan V. ; Parker, Matthew O. ; Rosemberg, Denis B. / Using zebrafish (Danio rerio) models to understand the critical role of social interactions in mental health and wellbeing. In: Progress in Neurobiology. 2021.

Bibtex

@article{107b877db40b424cbc78c8ff22f8cc88,
title = "Using zebrafish (Danio rerio) models to understand the critical role of social interactions in mental health and wellbeing",
abstract = "Social behavior represents a beneficial interaction between conspecifics that is critical for maintaining health and wellbeing. Dysfunctional or poor social interaction are associated with increased risk of physical (e.g., vascular) and psychiatric disorders (e.g., anxiety, depression and substance abuse). Although the impact of negative and positive social interactions is well-studied, their underlying mechanisms remain poorly understood. Zebrafish have well-characterized social behavior phenotypes, high genetic homology with humans, relative experimental simplicity and the potential for high-throughput screens. Here, we discuss the use of zebrafish as a candidate model organism for studying the mechanisms underlying social interactions, as well as potential impacts of social isolation on human health and wellbeing. Overall, the growing utility of zebrafish models may improve our understanding of how the presence and absence of social interactions can differently modulate molecular and physiological biomarkers, as well as other behaviors.",
keywords = "anxiety, depression, social interactions, social isolation, translational models, zebrafish",
author = "Fontana, {Barbara D.} and M{\"u}ller, {Talise E.} and Madeleine Cleal and {De Abreu}, {Murilo S.} and Norton, {William H.J.} and Demin, {Konstantin A.} and Amstislavskaya, {Tamara G.} and Petersen, {Elena V.} and Kalueff, {Allan V.} and Parker, {Matthew O.} and Rosemberg, {Denis B.}",
year = "2021",
month = jan,
day = "10",
doi = "10.1016/j.pneurobio.2021.101993",
language = "English",
journal = "Progress in Neurobiology",
issn = "0301-0082",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Using zebrafish (Danio rerio) models to understand the critical role of social interactions in mental health and wellbeing

AU - Fontana, Barbara D.

AU - Müller, Talise E.

AU - Cleal, Madeleine

AU - De Abreu, Murilo S.

AU - Norton, William H.J.

AU - Demin, Konstantin A.

AU - Amstislavskaya, Tamara G.

AU - Petersen, Elena V.

AU - Kalueff, Allan V.

AU - Parker, Matthew O.

AU - Rosemberg, Denis B.

PY - 2021/1/10

Y1 - 2021/1/10

N2 - Social behavior represents a beneficial interaction between conspecifics that is critical for maintaining health and wellbeing. Dysfunctional or poor social interaction are associated with increased risk of physical (e.g., vascular) and psychiatric disorders (e.g., anxiety, depression and substance abuse). Although the impact of negative and positive social interactions is well-studied, their underlying mechanisms remain poorly understood. Zebrafish have well-characterized social behavior phenotypes, high genetic homology with humans, relative experimental simplicity and the potential for high-throughput screens. Here, we discuss the use of zebrafish as a candidate model organism for studying the mechanisms underlying social interactions, as well as potential impacts of social isolation on human health and wellbeing. Overall, the growing utility of zebrafish models may improve our understanding of how the presence and absence of social interactions can differently modulate molecular and physiological biomarkers, as well as other behaviors.

AB - Social behavior represents a beneficial interaction between conspecifics that is critical for maintaining health and wellbeing. Dysfunctional or poor social interaction are associated with increased risk of physical (e.g., vascular) and psychiatric disorders (e.g., anxiety, depression and substance abuse). Although the impact of negative and positive social interactions is well-studied, their underlying mechanisms remain poorly understood. Zebrafish have well-characterized social behavior phenotypes, high genetic homology with humans, relative experimental simplicity and the potential for high-throughput screens. Here, we discuss the use of zebrafish as a candidate model organism for studying the mechanisms underlying social interactions, as well as potential impacts of social isolation on human health and wellbeing. Overall, the growing utility of zebrafish models may improve our understanding of how the presence and absence of social interactions can differently modulate molecular and physiological biomarkers, as well as other behaviors.

KW - anxiety

KW - depression

KW - social interactions

KW - social isolation

KW - translational models

KW - zebrafish

U2 - 10.1016/j.pneurobio.2021.101993

DO - 10.1016/j.pneurobio.2021.101993

M3 - Article

JO - Progress in Neurobiology

JF - Progress in Neurobiology

SN - 0301-0082

M1 - 101993

ER -

ID: 25696393