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Vascular endothelial growth factor release following coronary artery bypass surgery: extracorporeal circulation versus 'beating heart' surgery

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Vascular endothelial growth factor release following coronary artery bypass surgery : extracorporeal circulation versus 'beating heart' surgery. / Burton, P. B. J.; Owen, V. J.; Hafizi, Sassan; Barton, P. J. R.; Carr-White, G.; Koh, T.; De Souza, A.; Yacoub, Magdi H.; Pepper, J. R.

In: European Heart Journal, Vol. 21, No. 20, 10.2000, p. 1708-1713.

Research output: Contribution to journalArticlepeer-review

Harvard

Burton, PBJ, Owen, VJ, Hafizi, S, Barton, PJR, Carr-White, G, Koh, T, De Souza, A, Yacoub, MH & Pepper, JR 2000, 'Vascular endothelial growth factor release following coronary artery bypass surgery: extracorporeal circulation versus 'beating heart' surgery', European Heart Journal, vol. 21, no. 20, pp. 1708-1713. https://doi.org/10.1053/euhj.2000.2177

APA

Burton, P. B. J., Owen, V. J., Hafizi, S., Barton, P. J. R., Carr-White, G., Koh, T., De Souza, A., Yacoub, M. H., & Pepper, J. R. (2000). Vascular endothelial growth factor release following coronary artery bypass surgery: extracorporeal circulation versus 'beating heart' surgery. European Heart Journal, 21(20), 1708-1713. https://doi.org/10.1053/euhj.2000.2177

Vancouver

Author

Burton, P. B. J. ; Owen, V. J. ; Hafizi, Sassan ; Barton, P. J. R. ; Carr-White, G. ; Koh, T. ; De Souza, A. ; Yacoub, Magdi H. ; Pepper, J. R. / Vascular endothelial growth factor release following coronary artery bypass surgery : extracorporeal circulation versus 'beating heart' surgery. In: European Heart Journal. 2000 ; Vol. 21, No. 20. pp. 1708-1713.

Bibtex

@article{d14a95896b0e410bbb2355f47334f700,
title = "Vascular endothelial growth factor release following coronary artery bypass surgery: extracorporeal circulation versus 'beating heart' surgery",
abstract = "Aims - The aim of this study was to examine the circulating levels of vascular endothelial growth factor, following coronary artery bypass graft surgery performed using both standard cardiopulmonary bypass or the {\textquoteleft}octopus technique{\textquoteright} on the beating heart.Background - Vascular endothelial growth factor has a number of effects that are beneficial in the setting of coronary artery bypass graft surgery including cardioprotection, potent angiogenic activity and amelioration of intimal hyperplasia. Hypoxia is a powerful stimulator of vascular endothelial growth factor expression yet the ability of ischaemia, occurring during coronary artery bypass graft surgery, to induce vascular endothelial growth factor production is unknown.Methods and Results - Serum vascular endothelial growth factor levels were determined in patients undergoing coronary artery bypass graft surgery with standard cardiopulmonary bypass (CPB-CABG group; n=20), with off-pump coronary artery bypass; (OP-CABG; n=12) and in patients undergoing non-cardiac major surgery (n=6). The effect of hypoxia on vascular endothelial growth factor release by neonatal rat cardiac myocytes in vitro was studied.In the CPB-CABG group vascular endothelial growth factor levels were significantly increased to 78·5±39·3 and 110·5±16·3pg.μl−18 and 24h post-operatively, declining to 14·9±9·9pg.μl−1by 48h to pre-operative values (14·4±8·6pg.μl−1). Significantly higher vascular endothelial growth factor levels were also present in the OP-CABG group 3, 6 and 24h post-operatively (levels 136·6±29·3, 143±26·12pg.μl−1and 93·5±20·1pg.μl−1, respectively). However, non-cardiac major surgery did not result in elevated vascular endothelial growth factor levels post-operatively (46·36±9·76 vs pre-surgery levels of 26·84±6·1pg.μl−1). Either 15min or 3h of hypoxia stimulated vascular endothelial growth factor release from neonatal rat cardiac myocytes in vitro. Twenty-four and 48h post hypoxia, levels of vascular endothelial growth factor were significantly elevated by approximately 17·5- and 48·5-fold respectively.Conclusions - These data demonstrate myocardial ischaemia secondary to CPB-CABG and OP-CABG to be a potent stimulator of vascular endothelial growth factor production, which may have implications for graft endothelialization and cardiovascular haemodynamics post-operatively.",
author = "Burton, {P. B. J.} and Owen, {V. J.} and Sassan Hafizi and Barton, {P. J. R.} and G. Carr-White and T. Koh and {De Souza}, A. and Yacoub, {Magdi H.} and Pepper, {J. R.}",
year = "2000",
month = oct,
doi = "10.1053/euhj.2000.2177",
language = "English",
volume = "21",
pages = "1708--1713",
journal = "European Heart Journal",
issn = "0195-668X",
publisher = "Oxford University Press",
number = "20",

}

RIS

TY - JOUR

T1 - Vascular endothelial growth factor release following coronary artery bypass surgery

T2 - extracorporeal circulation versus 'beating heart' surgery

AU - Burton, P. B. J.

AU - Owen, V. J.

AU - Hafizi, Sassan

AU - Barton, P. J. R.

AU - Carr-White, G.

AU - Koh, T.

AU - De Souza, A.

AU - Yacoub, Magdi H.

AU - Pepper, J. R.

PY - 2000/10

Y1 - 2000/10

N2 - Aims - The aim of this study was to examine the circulating levels of vascular endothelial growth factor, following coronary artery bypass graft surgery performed using both standard cardiopulmonary bypass or the ‘octopus technique’ on the beating heart.Background - Vascular endothelial growth factor has a number of effects that are beneficial in the setting of coronary artery bypass graft surgery including cardioprotection, potent angiogenic activity and amelioration of intimal hyperplasia. Hypoxia is a powerful stimulator of vascular endothelial growth factor expression yet the ability of ischaemia, occurring during coronary artery bypass graft surgery, to induce vascular endothelial growth factor production is unknown.Methods and Results - Serum vascular endothelial growth factor levels were determined in patients undergoing coronary artery bypass graft surgery with standard cardiopulmonary bypass (CPB-CABG group; n=20), with off-pump coronary artery bypass; (OP-CABG; n=12) and in patients undergoing non-cardiac major surgery (n=6). The effect of hypoxia on vascular endothelial growth factor release by neonatal rat cardiac myocytes in vitro was studied.In the CPB-CABG group vascular endothelial growth factor levels were significantly increased to 78·5±39·3 and 110·5±16·3pg.μl−18 and 24h post-operatively, declining to 14·9±9·9pg.μl−1by 48h to pre-operative values (14·4±8·6pg.μl−1). Significantly higher vascular endothelial growth factor levels were also present in the OP-CABG group 3, 6 and 24h post-operatively (levels 136·6±29·3, 143±26·12pg.μl−1and 93·5±20·1pg.μl−1, respectively). However, non-cardiac major surgery did not result in elevated vascular endothelial growth factor levels post-operatively (46·36±9·76 vs pre-surgery levels of 26·84±6·1pg.μl−1). Either 15min or 3h of hypoxia stimulated vascular endothelial growth factor release from neonatal rat cardiac myocytes in vitro. Twenty-four and 48h post hypoxia, levels of vascular endothelial growth factor were significantly elevated by approximately 17·5- and 48·5-fold respectively.Conclusions - These data demonstrate myocardial ischaemia secondary to CPB-CABG and OP-CABG to be a potent stimulator of vascular endothelial growth factor production, which may have implications for graft endothelialization and cardiovascular haemodynamics post-operatively.

AB - Aims - The aim of this study was to examine the circulating levels of vascular endothelial growth factor, following coronary artery bypass graft surgery performed using both standard cardiopulmonary bypass or the ‘octopus technique’ on the beating heart.Background - Vascular endothelial growth factor has a number of effects that are beneficial in the setting of coronary artery bypass graft surgery including cardioprotection, potent angiogenic activity and amelioration of intimal hyperplasia. Hypoxia is a powerful stimulator of vascular endothelial growth factor expression yet the ability of ischaemia, occurring during coronary artery bypass graft surgery, to induce vascular endothelial growth factor production is unknown.Methods and Results - Serum vascular endothelial growth factor levels were determined in patients undergoing coronary artery bypass graft surgery with standard cardiopulmonary bypass (CPB-CABG group; n=20), with off-pump coronary artery bypass; (OP-CABG; n=12) and in patients undergoing non-cardiac major surgery (n=6). The effect of hypoxia on vascular endothelial growth factor release by neonatal rat cardiac myocytes in vitro was studied.In the CPB-CABG group vascular endothelial growth factor levels were significantly increased to 78·5±39·3 and 110·5±16·3pg.μl−18 and 24h post-operatively, declining to 14·9±9·9pg.μl−1by 48h to pre-operative values (14·4±8·6pg.μl−1). Significantly higher vascular endothelial growth factor levels were also present in the OP-CABG group 3, 6 and 24h post-operatively (levels 136·6±29·3, 143±26·12pg.μl−1and 93·5±20·1pg.μl−1, respectively). However, non-cardiac major surgery did not result in elevated vascular endothelial growth factor levels post-operatively (46·36±9·76 vs pre-surgery levels of 26·84±6·1pg.μl−1). Either 15min or 3h of hypoxia stimulated vascular endothelial growth factor release from neonatal rat cardiac myocytes in vitro. Twenty-four and 48h post hypoxia, levels of vascular endothelial growth factor were significantly elevated by approximately 17·5- and 48·5-fold respectively.Conclusions - These data demonstrate myocardial ischaemia secondary to CPB-CABG and OP-CABG to be a potent stimulator of vascular endothelial growth factor production, which may have implications for graft endothelialization and cardiovascular haemodynamics post-operatively.

U2 - 10.1053/euhj.2000.2177

DO - 10.1053/euhj.2000.2177

M3 - Article

VL - 21

SP - 1708

EP - 1713

JO - European Heart Journal

JF - European Heart Journal

SN - 0195-668X

IS - 20

ER -

ID: 227511