Vascular responses of the extremities to transdermal application of vasoactive agents in Caucasian and African descent individuals
Research output: Contribution to journal › Article › peer-review
Methods - Twenty-four young males (12 CAU and 12 AFD) undertook three tests in which iontophoresis was used to apply acetylcholine (ACh 1 w/v %), sodium nitroprusside (SNP 0.01 w/v %) and noradrenaline (NA 0.5 mM) to the skin. The skin sites tested were: volar forearm, non-glabrous finger and toe, and glabrous finger (pad) and toe (pad).
Results - In response to SNP on the forearm, AFD had less vasodilatation for a given current application than CAU (P = 0.027–0.004). ACh evoked less vasodilatation in AFD for a given application current in the non-glabrous finger and toe compared with CAU (P = 0.043–0.014) with a lower maximum vasodilatation in the non-glabrous finger (median [interquartile], AFD n = 11, 41 %, CAU n = 12, 351 %, P = 0.011) and non-glabrous toe (median [interquartile], AFD n = 9, 116 %, CAU n = 12, 484 %, P = 0.018). ACh and SNP did not elicit vasodilatation in the glabrous skin sites of either group. There were no ethnic differences in response to NA.
Conclusion - AFD have an attenuated endothelium-dependent vasodilatation in non-glabrous sites of the fingers and toes compared with CAU. This may contribute to lower skin temperature following cold exposure and the increased risk of cold injuries experienced by AFD.
|Number of pages||11|
|Journal||European Journal of Applied Physiology|
|Early online date||4 Apr 2015|
|Publication status||Published - 1 Aug 2015|
- Vascular responses of the extremities
Rights statement: This is a post-peer-review, pre-copyedit version of an article published in the European Journal of Applied Physiology. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00421-015-3164-2.
Accepted author manuscript (Post-print), 256 KB, PDF document