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Vinylpyrrolidone-co-(meth)acrylic acid inserts for ocular drug delivery: synthesis and evaluation

Research output: Contribution to journalArticle

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Vinylpyrrolidone-co-(meth)acrylic acid inserts for ocular drug delivery : synthesis and evaluation. / Barbu, Eugen; Sarvaiya, Indrajeetsinh; Green, Keith L; Nevell, Thomas G; Tsibouklis, John.

In: Journal of Biomedical Materials Research Part A, Vol. 74A, No. 4, 15.09.2005, p. 598-606.

Research output: Contribution to journalArticle

Harvard

Barbu, E, Sarvaiya, I, Green, KL, Nevell, TG & Tsibouklis, J 2005, 'Vinylpyrrolidone-co-(meth)acrylic acid inserts for ocular drug delivery: synthesis and evaluation', Journal of Biomedical Materials Research Part A, vol. 74A, no. 4, pp. 598-606. https://doi.org/10.1002/jbm.a.v74a:4

APA

Barbu, E., Sarvaiya, I., Green, K. L., Nevell, T. G., & Tsibouklis, J. (2005). Vinylpyrrolidone-co-(meth)acrylic acid inserts for ocular drug delivery: synthesis and evaluation. Journal of Biomedical Materials Research Part A, 74A(4), 598-606. https://doi.org/10.1002/jbm.a.v74a:4

Vancouver

Barbu E, Sarvaiya I, Green KL, Nevell TG, Tsibouklis J. Vinylpyrrolidone-co-(meth)acrylic acid inserts for ocular drug delivery: synthesis and evaluation. Journal of Biomedical Materials Research Part A. 2005 Sep 15;74A(4):598-606. https://doi.org/10.1002/jbm.a.v74a:4

Author

Barbu, Eugen ; Sarvaiya, Indrajeetsinh ; Green, Keith L ; Nevell, Thomas G ; Tsibouklis, John. / Vinylpyrrolidone-co-(meth)acrylic acid inserts for ocular drug delivery : synthesis and evaluation. In: Journal of Biomedical Materials Research Part A. 2005 ; Vol. 74A, No. 4. pp. 598-606.

Bibtex

@article{114cc8d4db3e4bdcb0de1bb64fdee09e,
title = "Vinylpyrrolidone-co-(meth)acrylic acid inserts for ocular drug delivery: synthesis and evaluation",
abstract = "Copolymeric hydrogels constituting of vinylpyrrolidone and methacrylic or acrylic acid repeat units have been prepared and investigated for their ability to act as controlled release vehicles in ophthalmic drug delivery. The materials were synthesized by radical-induced polymerization in the presence of N,N′-methylenebisacrylamide crosslinker, and the influences of network composition and drug solubility upon the swelling properties, adhesion behavior, and drug release characteristics were studied. In vitro release experiments showed that some of these materials could be useful vehicles for the delivery of drugs such as pilocarpine or chloramphenicol, while in vivo studies, using the rabbit model, confirmed their high potential for the controlled ocular delivery of pilocarpine hydrochloride.",
author = "Eugen Barbu and Indrajeetsinh Sarvaiya and Green, {Keith L} and Nevell, {Thomas G} and John Tsibouklis",
year = "2005",
month = "9",
day = "15",
doi = "10.1002/jbm.a.v74a:4",
language = "English",
volume = "74A",
pages = "598--606",
journal = "Journal of Biomedical Materials Research Part A",
issn = "1549-3296",
publisher = "John Wiley and Sons Inc.",
number = "4",

}

RIS

TY - JOUR

T1 - Vinylpyrrolidone-co-(meth)acrylic acid inserts for ocular drug delivery

T2 - synthesis and evaluation

AU - Barbu, Eugen

AU - Sarvaiya, Indrajeetsinh

AU - Green, Keith L

AU - Nevell, Thomas G

AU - Tsibouklis, John

PY - 2005/9/15

Y1 - 2005/9/15

N2 - Copolymeric hydrogels constituting of vinylpyrrolidone and methacrylic or acrylic acid repeat units have been prepared and investigated for their ability to act as controlled release vehicles in ophthalmic drug delivery. The materials were synthesized by radical-induced polymerization in the presence of N,N′-methylenebisacrylamide crosslinker, and the influences of network composition and drug solubility upon the swelling properties, adhesion behavior, and drug release characteristics were studied. In vitro release experiments showed that some of these materials could be useful vehicles for the delivery of drugs such as pilocarpine or chloramphenicol, while in vivo studies, using the rabbit model, confirmed their high potential for the controlled ocular delivery of pilocarpine hydrochloride.

AB - Copolymeric hydrogels constituting of vinylpyrrolidone and methacrylic or acrylic acid repeat units have been prepared and investigated for their ability to act as controlled release vehicles in ophthalmic drug delivery. The materials were synthesized by radical-induced polymerization in the presence of N,N′-methylenebisacrylamide crosslinker, and the influences of network composition and drug solubility upon the swelling properties, adhesion behavior, and drug release characteristics were studied. In vitro release experiments showed that some of these materials could be useful vehicles for the delivery of drugs such as pilocarpine or chloramphenicol, while in vivo studies, using the rabbit model, confirmed their high potential for the controlled ocular delivery of pilocarpine hydrochloride.

U2 - 10.1002/jbm.a.v74a:4

DO - 10.1002/jbm.a.v74a:4

M3 - Article

VL - 74A

SP - 598

EP - 606

JO - Journal of Biomedical Materials Research Part A

JF - Journal of Biomedical Materials Research Part A

SN - 1549-3296

IS - 4

ER -

ID: 3931931