Zebrafish models for attention deficit hyperactivity disorder (ADHD)
Research output: Contribution to journal › Review article › peer-review
Attention deficit hyperactivity disorder (ADHD) is a common, debilitating neurodevelopmental disorder associated with inattentiveness, pathological hyperactivity and impulsivity. Despite the mounting human and animal evidence, the neurological pathways underlying ADHD remain poorly understood. Novel translational model organisms, such as the zebrafish (Danio rerio), are becoming important tools to investigate genetic and pathophysiological mechanisms of various neuropsychiatric disorders. Here, we discuss ADHD etiology, existing rodent models and their limitations, and emphasize the advantages of using zebrafish to model ADHD. Overall, the growing utility of zebrafish models may improve our understanding of ADHD and facilitate drug discovery to prevent or treat this disorder.
| Original language | English |
|---|---|
| Pages (from-to) | 9-18 |
| Number of pages | 10 |
| Journal | Neuroscience and Biobehavioral Reviews |
| Volume | 100 |
| Early online date | 16 Feb 2019 |
| DOIs | |
| Publication status | Published - 1 May 2019 |
Documents
- Zebrafish models for attention deficit hyperactivity disorder
Accepted author manuscript (Post-print), 495 KB, PDF document
Licence: CC BY-NC-ND
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Projects
Characterization of zebrafish genetic models of ADHD
Project: Research
ID: 13161304
