Procoagulant activity, airway remodelling and inflammation in moderate and severe asthma
Student thesis: Doctoral Thesis
Asthma is a chronic disease characterised by airway inflammation and remodelling. Inhaled corticosteroids (ICS) are the cornerstone of asthma therapy, and yet many asthmatics remain symptomatic, some with severe manifestations of the disease. The bronchial epithelium produces coagulation factors locally in the absence of plasma exudation. There is evidence in asthma that there is upregulation and stimulation of the external coagulation cascade in the airways, and locally derived factors may be involved.